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Easy Bison Meatloaf Recipe

Are you ready to cook up a healthy alternative to ground beef? Then my Easy Bison Meatloaf Recipe is perfect for you!

This recipe is packed with Italian flavors, real ingredients and is great for any night of the week.

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upclose picture of bison meatloaf
Bison Meatloaf

Ingredients needed for this Bison Meatloaf

  • ground bison
  • organic ketchup 
  • gluten free breadcrumbs  (or any seasoned breadcrumbs if you don’t need it to be gluten free)
  • white onion small
  • garlic cloves
  • egg and egg white
  • Italian truffle cheese (or any shredded soft cheese such as mozzarella, pepper jack or provolone)
  • fresh basil 
  • spices such ground thyme, paprika, oregano, dried parsley
  • kosher salt 
  • olive oil 
  • fresh parsley optional, garnish
bison meatloaf ingredients

How to prepare this Easy Bison Meatloaf

  1. Start with preheating the oven at 350 degrees. In a large mixing bowl, add the bison along with the bread crumbs, 1/2 cup of ketchup, onions, garlic, egg and egg white, seasonings, basil and cheese.
  2. Mix together with your hands(using gloves is optional) and season with more salt if you desire. 
  3. Coat your meatloaf pan with the olive oil. Take the bison mixture and shape it into the meatloaf pan.
  4. Place the meatloaf on top of a sheet pan and put it in the oven to bake for about 1 hour. Half way through cooking, add the additional ketchup on top.
  5. Bison should reach 160 degrees internal temperature. You will want to use a meat thermometer or instant read themometer for accuracy. Be sure to place the thermometer in the middle of the loaf when temping.
  6. When done, carefully remove the bison meatloaf from the oven and sprinkle top with fresh parsley if desired. Let the meatloaf cool before cutting into it.
  7. Store any leftovers in an airtight container in the fridge for up to 2-3 days.

What Kind of Cheese is in This Easy BisonMeatloaf Recipe

I use Italian Truffle Cheese(sounds pretty fancy I know) from Trader Joe’s. It comes in a block and can be easily shredded with a cheese grater. You can substitute this with a soft shreddable cheese such as provolone, mozzarella or pepper jack. Parmesan cheese could work too, but I like the texture the soft cheese gives in the meatloaf.

Other substitutions

I use gluten free breadcrumbs in this dish. However any type of breadcrumbs will work if you do not need it to be gluten free.

Regular ketchup can be used.

The flavors in the meatloaf will also taste good with ground turkey or ground beef or pork.

What is the Difference Between Bison and Beef

Bison comes from buffalo whereas beef comes from cows. Bison is a great way to switch up your proteins. Also it is lower in fat.

What Are Other Ways to Cook Bison

There are many ways to enjoy Bison meat! I like to use it as hamburger meat, chili, tacos and meatballs. Basically anything you would normally eat ground beef in, you can replace it with bison.

And after many years of cooking bison, it’s all about how you season it. You can mix buffalo with lots of different spices and sauces.

Helpful tools for preparing Easy Bison Meatloaf Recipe

For starters you will want to use a loaf pan so that you can have a nice oval shape. But you can also use a small casserole dish and form the meatloaf into as you would in a loaf pan.

I highly recommend using a baking sheet pan underneath your loaf pan so that you can prevent any juice spillage into your oven.

A food processor is handy for chopping the onion and garlic. It also helps with releasing all that juice which will flavor up the meatloaf even more.

To make it easier to lift out the meatloaf from the pan, you can line it with parchment paper. Another alternative is to coat with oil or spray your loaf pan.

Make sure to have a large bowl ready for mixing all of your ingredients and also a pair of food safe rubber gloves if you don’t want to get your hands dirty!

What Do I Eat This Meatloaf Recipe With

Meatloaf is the ultimate comfort food! You can enjoy this with regular mash potatoes, or if you want to keep it light, cauliflower mash potatoes and green beans or another vegetable of your choice.

Leftovers are great for making a cold meatloaf sandwich! Oh you heard me right! A little bit of mayo, a slice of American cheese, touch of sprouts and some good white bread and your meatloaf slice just got reinvented.

Bison Meatloaf is also delicious in meal prep with fresh cooked jasmine rice as my husband likes to enjoy his.

At What Temperature is Bison Considered Cooked

You will want to cook your meatloaf until the center-most part reaches the internal temperature of 160 degrees.

Looking for more dinner recipes? Definitely check out:

Easy Rosemary Shaved Beef Recipe

30 Minute Healthy Sloppy Joe’s

Where Can I Purchase Ground Bison

You can find bison at your local grocery store. I find Costco to have the best prices on ground bison meat. It comes in a 2 pack package.

close up picture of easy bison meatloaf recipe

Why I Created This Specific Recipe

I have been making meatloaf for years and I have created many different recipes and variations. I used to use Manwich as my secret weapon and regular breadcrumbs like Progresso. But I wanted to revamp this classic and turn it into how I eat today.

This recipe uses real ingredients and is gluten free.

You can use my Gluten Free bread crumbs recipe or you can sub out with another kind. I also use organic ketchup. There are a few on the market and I have bounced between brands. But I like the affordability of Woodstock Foods. (This is not sponsored, I just really love their organic ketchup)

Heinz also makes organic ketchup. You can always use regular ketchup as well.

Are you Ready to Give This New Recipe a Try

Looking for more healthy dinner ideas? Sign up for my newsletter and receive new recipes sent straight to your inbox!

Want to serve this with a gluten free side dish? Check out my Cumin Sweet Potatoes!

Let’s Make This Easy Bison Meatloaf Recipe!

easy bison meatloaf recipe

Easy Bison Meatloaf Recipe

A delicious and healthy alternative to beef- This easy Bison Meatloaf is tasty and will soon become a family favorite!
5 from 3 votes
Prep Time 20 minutes
Cook Time 1 hour 15 minutes
Course Dinner, Main Course
Cuisine American
Servings 8
Calories 223 kcal


  • 1 pound ground bison
  • 1/2 cup organic ketchup to be mixed in
  • 1/3 cup organic ketchup for topping
  • 1 cup gluten free breadcrumbs or any seasoned breadcrumbs
  • 1 small white onion small chopped
  • 5 garlic cloves minced
  • 1 large egg
  • 1 large egg white
  • 1/2 cup Italian truffle cheese or any shredded soft cheese such as mozzarella, pepper jack or provolone
  • 1/4 cup fresh basil 1 .5 ounce pack
  • 1/4 teaspoon ground thyme
  • 1 teaspoon paprika
  • 1 teaspoon oregano
  • 1 teaspoon dried parsley
  • 1/2 teaspoon kosher salt plus more if needed
  • olive oil to coat pan
  • fresh parsley optional, garnish


  • Preheat the oven at 350 degrees.
  • In a large mixing bowl, add the bison along with the bread crumbs, 1/2 cup of ketchup, onions, garlic, egg and egg white, seasonings, basil and cheese.
  • Mix together with your hands and season with more salt if you desire.
  • Coat the meatloaf pan with the olive oil.
  • Take the meat and shape into the meatloaf pan.
  • Put the meatloaf on top of a sheet pan and place in the oven to bake for about 1 hour. Half way through cooking, add the additional ketchup on top.
  • Bison should reach 160 degrees internal temperature.
  • When done, carefully remove from the oven and sprinkle top of loaf with fresh parsley if desired. Let the meatloaf cool before cutting into it.
  • For leftovers, slice meatloaf and store into an airtight container.
  • Enjoy!


Please Note: Placing the meatloaf pan on top of a sheet pan will help any juices that may spill over.
*I use a double oven and baked this on the bottom half and the very lowest rack and it took 1 hour and 15 minutes to cook.* 
Italian Truffle Cheese can be found at Trader Joe’s and can be substituted with any kind of soft shreddable cheese like mozzarella, pepper jack or provolone.
Organic ketchup keeps the recipe clean however it substituted with regular ketchup.


Calories: 223kcalCarbohydrates: 12gProtein: 15gFat: 12gSaturated Fat: 5gPolyunsaturated Fat: 1gMonounsaturated Fat: 4gTrans Fat: 0.003gCholesterol: 68mgSodium: 244mgPotassium: 227mgFiber: 1gSugar: 2gVitamin A: 250IUVitamin C: 1mgCalcium: 57mgIron: 2mg
Keyword Bison Meatloaf, Gluten Free Meatloaf, Healthy Meatloaf
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